Efficient fiber Bragg grating and fiber Fabry-Pe'rot sensor multiplexing scheme using a broadband pulsed mode-locked laser

A pulsed broadband mode-locked laser (MLL) combined with interferometric interrogation is shown to yield an efficient means of multiplexing a large number of fiber Bragg grating (FBG) or fiber Fabry-Perot (FFP) strain sensors with high performance. System configurations utilizing time division multiplexing (TDM) permit high resolution, accuracy, and bandwidth strain measurements along with high sensor densities. Strain resolutions of 23-60 n epsilon/Hz(1/2) at frequencies up to 800 Hz (expandable to 139 kHz) and a differential strain-measurement accuracy of +/- 1 mu epsilon are demonstrated. Interrogation of a low-finesse FFP sensor is also demonstrated, from which a strain resolution of 2 n epsilon/Hz(1/2) and strain-measurement accuracy of +/- 31 n epsilon are achieved. The system has the capability of interrogating well in excess of 50 sensors per fiber depending on crosstalk requirements. A discussion on sensor spacing, bandwidth, dynamic range, and measurement accuracy is also given

Polarization properties of interferometrically interrogated fiber Bragg grating and tandem-interferometer strain sensors

Lead sensitivity in low-coherence interferometric fiber-optic sensors is a well-known problem. It can lead to a severe degradation in the sensor resolution and accuracy through its effect on the fringe visibility and interferometric phase. These sensitivities have been attributed to birefringence in the various components. In the current work, an analysis of the polarization properties of fiber Bragg grating and tandem-interferometer strain sensors, using Stokes calculus and the Poincare sphere, is presented. The responses of these sensors as a function of the birefringence properties of the various components under different illuminating conditions are derived. The predicted responses demonstrate very good agreement with experimentally measured responses. These models provide a clear insight into the evolution of the polarization states through the sensor networks. Methods to overcome the lead sensitivity are discussed and demonstrated, which yield a differential strain measurement accuracy of 18 n epsilon - rms for a fiber Bragg grating sensor

Efficient large-scale multiplexing of fiber Bragg grating and fiber Fabry-Perot sensors for structural health monitoring applications

Fiber Bragg gratings have been demonstrated as a versatile sensor for structural health monitoring. We present an efficient and cost effective multiplexing method for fiber Bragg grating and fiber Fabry-Perot sensors based on a broadband mode-locked fiber laser source and interferometric interrogation. The broadband, pulsed laser source permits time and wavelength division multiplexing to be employed to achieve very high sensor counts. Interferometric interrogation also permits high strain resolutions over large frequency ranges to be achieved. The proposed system has the capability to interrogate several hundred fiber Bragg gratings or fiber Fabry-Perot sensors on a single fiber, whilst achieving sub-microstrain resolution over bandwidths greater than 100 kHz. Strain resolutions of 30n epsilon/Hz(1/2) and 2 n epsilon/Hz(1/2) are demonstrated with the fiber Bragg grating and fiber Fabry-Perot sensor respectively. The fiber Fabry-Perot sensor provides an increase in the strain resolution over the fiber Bragg grating sensor of greater than a factor of 10. The fiber Bragg gratings are low reflectivity and could be fabricated during the fiber draw process providing a cost effective method for array fabrication. This system would find applications in several health monitoring applications where large sensor counts are necessary, in particular acoustic emission

Ultra-high-sensitivity two-dimensional bend sensor

A multicore fibre Fabry-Perot-based strain sensor interrogated with tandem interferometry for bend measurement is described. Curvature in two dimensions is obtained by measuring the difference in strain between three co-located low finesse Fabry-Perot interferometers formed in each core of the fibre by pairs of Bragg gratings. This sensor provides a responsivity enhancement of up to 30 times that of a previously reported fibre Bragg grating based sensor. Strain resolutions of 0.6 n epsilon/Hz(1/2) above 1 Hz are demonstrated, which corresponds to a curvature resolution of similar to 0.012 km(-1)/Hz(1/2)

Two-axis bend measurement with Bragg gratings in multicore optical fiber

We describe what is to our knowledge the first use of fiber Bragg gratings written into three separate cores of a multicore fiber for two-axis curvature measurement. The gratings act as independent, but isothermal, fiber strain gauges for which local curvature determines the difference in strain between cores, permitting temperature-independent bend measurement. (C) 2003 Optical Society of America

Characterization of custom-made thin film AlN MEMS ultrasound transducers

Photoacoustic (PA) imaging and sensing has attracted a lot of attention in biomedical applications. This is due to its potential in improved specificity and resolution when compared to using ultrasound as imaging source [1]. In the presented work we focus on the miniaturization of custom MEMS ultrasound receivers for applications in PA detection. These devices are of interest as they can lead to broad bandwidth transducers and have the potential for mass production with a reduction in cost [2]. The array of MEMS ultrasound receivers are fabricated using a cost-efficient multi-user process (PiezoMUMPs) and consist of a 500 nm thick film of aluminium nitride as piezo-active layer on a 10 µm thick silicon-on-insulator wafer. A multi-element single bandwidth and a multi-bandwidth MEMS chip have been designed with a centre frequency of 1.3 MHz and centre frequencies of 1.15 MHz, 0.75 MHz, 0.45 MHz, 0.3 MHz (smallest to largest diameter), respectively (see Fig. 1). The designs were immersed in an oil bath and characterized using the pitch-catch technique and PA excitation. The PA excitation was generated using a 10 ns Nd:YAG laser (Brilliant B, Quantel) at 532 nm and a pulse repetition frequency of 10 Hz with pulse energies of 2.6 mJ, focussed with a 30 mm lens onto a highly absorbing gelatine phantom. The devices’ performance in ultrasound and PA wave detection will be shown and their advantages discussed

Design and modelling of solidly mounted resonators for low-cost particle sensing

This work presents the design and fabrication of Solidly Mounted Resonator (SMR) devices for the detection of particulate matter (PM2.5 and PM10) in order to develop a smart low-cost particle sensor for air quality. These devices were designed to operate at a resonant frequency of either 870 MHz or 1.5 GHz, employing zinc oxide as the piezoelectric layer and an acoustic mirror made from molybdenum and silicon dioxide layers. Finite element analysis of the acoustic resonators was performed using COMSOL Multiphysics software in order to evaluate the frequency response of the devices and the performance of the acoustic mirror. The zinc oxide based acoustic resonators were fabricated on a silicon substrate using a five mask process. The mass sensitivity of the acoustic resonators was estimated using a 3-D finite element model and preliminary testing has been performed. The theoretical and observed mass sensitivity were similar at ca. 145 kHz/ng for the 870 MHz resonator when detecting PM2.5 suggesting that SMR devices have potential to be used as part of a miniature smart sensor system for airborne particle detection.This work was funded under the European Commission 7th Framework Programme, Project No. 611887, “Multi-Sensor-Platform for Smart Building Management: MSP”. F.H.Villa-Lopez thanks the financial support from the National Mexican Council of Science and Technology (CONACYT). G. Rughoobur wishes to acknowledge financial support from the Cambridge Trusts.This is the author accepted manuscript. The final version is available from IOP via http://dx.doi.org/10.1088/0957-0233/27/2/02510

Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100

Background: Bevacizumab has broad anti-tumour activity, but substantial risk of hypertension. No reliable markers are available for predicting bevacizumab-induced hypertension. Methods: A genome-wide association study (GWAS) was performed in the phase III bevacizumab-based adjuvant breast cancer trial, ECOG-5103, to evaluate for an association between genotypes and hypertension. GWAS was conducted in those who had experienced systolic blood pressure (SBP) >160 mm Hg during therapy using binary analysis and a cumulative dose model for the total exposure of bevacizumab. Common toxicity criteria (CTC) grade 3–5 hypertension was also assessed. Candidate SNP validation was performed in the randomised phase III trial, ECOG-2100. Results: When using the phenotype of SBP>160 mm Hg, the most significant association in SV2C (rs6453204) approached and met genome-wide significance in the binary model (P=6.0 × 10−8OR=3.3) and in the cumulative dose model (P=4.7 × 10−8HR=2.2), respectively. Similar associations with rs6453204 were seen for CTC grade 3–5 hypertension but did not meet genome-wide significance. Validation study from ECOG-2100 demonstrated a statistically significant association between this SNP and grade 3/4 hypertension using the binary model (P-value=0.037OR=2.4). Conclusions: A genetic variant in SV2C predicted clinically relevant bevacizumab-induced hypertension in two independent, randomised phase III trials

Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease

<p>Abstract</p> <p>Background</p> <p>Statins are a class of medications that reduce cholesterol by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Whether statins can benefit patients with dementia remains unclear because of conflicting results. We hypothesized that some of the confusion in the literature might arise from differences in efficacy of different statins. We used a large database to compare the action of several different statins to investigate whether some statins might be differentially associated with a reduction in the incidence of dementia and Parkinson's disease.</p> <p>Methods</p> <p>We analyzed data from the decision support system of the US Veterans Affairs database, which contains diagnostic, medication and demographic information on 4.5 million subjects. The association of lovastatin, simvastatin and atorvastatin with dementia was examined with Cox proportional hazard models for subjects taking statins compared with subjects taking cardiovascular medications other than statins, after adjusting for covariates associated with dementia or Parkinson's disease.</p> <p>Results</p> <p>We observed that simvastatin is associated with a significant reduction in the incidence of dementia in subjects ≥65 years, using any of three models. The first model incorporated adjustment for age, the second model included adjusted for three known risk factors for dementia, hypertension, cardiovascular disease or diabetes, and the third model incorporated adjustment for the Charlson index, which is an index that provides a broad assessment of chronic disease. Data were obtained for over 700000 subjects taking simvastatin and over 50000 subjects taking atorvastatin who were aged >64 years. Using model 3, the hazard ratio for incident dementia for simvastatin and atorvastatin are 0.46 (CI 0.44–0.48, <it>p </it>< 0.0001) and 0.91 (CI 0.80–1.02, <it>p </it>= 0.11), respectively. Lovastatin was not associated with a reduction in the incidence of dementia. Simvastatin also exhibited a reduced hazard ratio for newly acquired Parkinson's disease (HR 0.51, CI 0.4–0.55, <it>p </it>< 0.0001).</p> <p>Conclusion</p> <p>Simvastatin is associated with a strong reduction in the incidence of dementia and Parkinson's disease, whereas atorvastatin is associated with a modest reduction in incident dementia and Parkinson's disease, which shows only a trend towards significance.</p